Identification of pelvic lymph nodes with chlorophyllin after injection
into the uterine cervix: An experimental and clinical study.
Wang H., Tan Y., Wang X., Xie J. Lymphology 2000;34:69-76
First, the effects of chlorophyllin dye were tested in normal dogs by injecting their uteri with 0.3% sodium copper chlorophyllin, and the resulting dye concentrations in the bloodstream, determined spectrophotometrically, peaked after 4 hours and were almost undetectable at 18 hours, while dye persisted for at least 4 days in macrophages detected light- and electron-microscopically in stained retroperitoneal lymph nodes. In the excised lymph nodes, however, no morphological changes were seen.
Then, 24 cervical, and 20 endometrial, carcinoma patients undergoing both radical hysterectomy and lymphadenectomy were divided into a lymphatic colouration group of 23 patients and a lymphatic non-coloration (control) group of 21 patients; and 0.3% chlorophyllin was injected into the cervices of the former 5 days before elective lymphadenectomy. No complications were attributed to these injections. Thanks to the dye accumulation in the colouration group lymph nodes, significantly more of them than of control group lymph nodes could be identified, and their dissection took less time.
The use of chlorophyllin thus appeared to offer three benefits: (1) It is safe; (2) It facilitates lymph node identification and consequently, excision; and (3) It shortens operation times (see comment below) in patients undergoing radical hysterectomy with lymphadenectomy.
Dr. Chris' comment:
One wonders if, given the potent hemostatic effect of Chlorophyllin, which contains a cereal grass extract, that operating time may also have been shortened because of reduced bleeding at the operation site. One frequently sees this in clinical practice where wheatgrass, because it effectively reduces or stops small vessel bleeding so effectively, that adrenaline is often not required for vasoconstriction.
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