ウィートグラスに関する研究　医学論文からの要約集 (1/2)

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  1. The effect of experimental anemia of radioactive Co60-Chlorophyllin, its distribution in the body and the therapeutic effect of Co-Chlorophyllin on anemia. Tamura K. 1959. Keio J.Med. (Japan). Vol.36 (View abstract)

    When 5 mg of non-radioactive Co-chlorophyllin was injected before irradiation, inhibition of the decrease in the blood cell counts and promotion of recovery were more marked than in controls receiving no injections. Co-chlorophyllin increased the leucocyte count and hemoglobin content in rats and directly or indirectly stimulated hematopoiesis (blood formation). The radioactive Co-chlorophyllin was accumulated and was stored for a long time mostly in the reticulo-endothelial system (RES) such as the liver, spleen, and bone marrow. Co-chlorophyllin was injected intravenously in 200 cases of malignant tumor treated with irradiation. Compared with those in 70 cases treated with radiation alone, the increase in the hemoglobin content, erythrocyte, and leucocyte counts was more marked, and the inhibition of decrease in the blood cell counts was also stronger than in the uninjected group.

  2. An experimental study of its water soluble derivatives in wound healing. Smith L, Livingston A. Chlorophyll. Am. J. Surg. 1943. 62:358-369

    Wound healing involves an inflammatory (exudative) phase and a proliferative tissue growth and repair phase that presumably involves growth stimulating factors. This study tested various water soluble chlorophyll preparations and other agents including vitamin ointments and sulfathiazole on wounds created by excising portions of skin from rats, guinea pigs, rabbits and dogs. Response in rate of healing tended to be greater for chlorophyll than with other agents tested (the data is summarized in several tables not reproducible here).
    Conclusion: On the basis of these observations it is suggested that chlorophyll preparations should be used much more extensively in the treatment of wounds and burns.

  3. The distribution of the grass juice factor in plant and animal materials. Randle S, Sober H, Kohler G. J. Nutr. 1940. 20:459-466

    Guinea pigs were fed on winter milk plus various supplements. Those fed on a supplement rich in the grass juice factor (rye grass) showed strong growth.
    Various plants were assayed for the grass juice factor. Based on average weight gain in guinea pigs the best sources of this growth promoting substance were dehydrated cereal grass (cerophyl), rye grass, young white clover, peas, pea shells, cabbage, spinach. Cereal grasses are an excellent source of the factor but the amount present varies with the age of the plant.

  4. The grass juice factor. Kohler G, Randle S, Wagner, J. Soc. Biol. Chem. 1939. 128

    The grass juice factor was precipitated from grass juice or dehydrated grass by using acetone. It is necessary for the normal growth of rats and guinea pigs. Guinea pigs fed a rationed diet died in 3 to 10 weeks but when dehydrated grass was included in the same diet they grew normally.

  5. Growth stimulating properties of grass juice. Kohler G, Elvehjem C, Hart E. Science. 1936. 445

    Growth of rats is greater on a diet of summer milk than winter milk. When grass juice was added to the winter milk diet, growth increased from 2 to 4 grams a day. It was concluded that there are important water-soluble substances in the juice that affect the nutritive value of summer milk.

  6. The effect of stage of growth on the chemistry of the grasses. Kohler G. J. Biol. Chem. 1944. 152:215-223

    Younger grass tends to be richer in protein, soluble carbohydrates, carotene, vitamin C, thiamine and riboflavin. Using oats, Kohler found that several of the vitamins, protein, crude fat and chlorophyll reached peak concentrations at or near the jointing stage, hence the nutritive value of grass is likely to be optimal at this point.

  7. Studies on the constituents of green juice from young barley leaves. Effect on dietarily induced hypercholesterolemia in rats. Ohtake, H., Nonaka, S., Sawada, Y., Hagiwara, Y., Hagiwara, H., Kubota, K. 1985. J. Pharm. Soc. Japan. 105:1052-71.

    Substances extracted from barley leaf juice lowered plasma cholesterol (after 9 days) of rats fed on a high cholesterol diet.

  8. Studies on the constituents of green juice from young barley leaves. Antiulcer activity of fractions from barley juice. Ohtake, H., Yuasa, H., Komura, C. Miyauchi, T., Hagiwara, Y., Kubota, K. 1985. J. Pharm. Soc. Japan. 105:1046-51.

    Green juice and fractions from green juice of young barley leaves containing water soluble proteins and water soluble organic compounds showed anti- stomach ulcer activity in stressed rats.

  9. Mechanism of antimutagenicity of wheat sprout extracts. Peryt, B., Szmczyk, T., Lesca, P. 1992. Mut. Res. 269:201-215.

    A supernatant extract from wheat grass reduced the production of carcinogenic aromatic hydrocarbon (benzopyrene) derivatives. Inhibition of benzopyrene mutagenicity with non-chlorophyll containing wheat sprout extract suggests that chlorophyll is not the main compound responsible.

  10. Wheat grass juice in the treatment of active distal ulcerative colitis: A randomized double-blind placebo-controlled trial. Ben-Arye E.; Goldin E.; Wengrower D.; Stamper A.; Kohn R.; Berry E. 2002. Scand. J. Gastroenterology, Vol:37.4:444-449(6)

    A randomized, double-blind, placebo trial was undertaken with 23 patients in Israel. Treatment with wheatgrass juice (100 cc a day for one month) reduced the overall disease activity and severity of rectal bleeding in patients with active distal ulcerative colitis. No serious side effects were found. The authors concluded that wheat grass juice appeared effective and safe as a single or adjuvant treatment of active distal ulcerative colitis.

  11. Clinical experiences with chlorophyll preparations with particular reference to chronic osteomyelitis and chronic ulcers. Carpenter B. 1949 Am. J. Surg. 77:167-171

    A clinical study using chlorophyll preparations to treat chronic osteomyelitis, osteomyelitis secondary to compound fractures and chronically infected wounds and ulcers. The study included many patients that had been resistant to other forms of therapy. The author considered chlorophyll preparations not necessarily a cure, but was interested to find such rapid eradication of infection and healing of wounds. Photos show epithelialization and healing of lesions, chronic ulcers and a grossly infected amputation stump. In many of the wound healing and ulcer cases there was no evidence of recurrence of infection or of breakdown at 18 months.

  12. Chlorophyll and wound healing. Experimental and clinical study. Lam, C., Brush, B. 1950 Am. J. Surg. 8:204-210 1950.

    Chlorophyll was used in an experiment with cutaneous wounds in guinea pigs, and in treating dermatome donor sites, clinical burns and surgical wounds and ulcers in human patients. Wound healing in guinea pigs showed acceleration in only 30% of cases, and did not enhance healing time for dermatome grafts. In clinical burns cases the chlorophyll ointment was a satisfactory dressing but did not appear to contribute to wound healing.

  13. Chlorophyll in wound healing and suppurative disease. Bowers, W. 1947. Am. J. Surg. 1947;73:37-50.

    Lieutenant Colonel Bowers of the US Army reports on the use of water-soluble derivatives of chlorophyll in over 400 cases over a period of nine months. He (and colleagues) noted several major effects, notably: loss of odour associated with infected wounds; a stimulating effect on tissue formation (granulation tissue) when used as a dressing particularly for burns; and a drying effect in the case of abscesses, sinus tracts, surface lesions and osteomyelitis. Mention is made of chlorophyll efficacy in treatment of cyst wounds, fistula-in-ano (6 cases), sarcoma/carcinoma (4 cases), ulcerative colitis (1 case), thoracic empyema (several cases, 2 particularly effective), gunshot wound sinus tracts (17 cases), decubitis ulcer (4 cases) and burns (4 patients). In 119 cases of compound fractures to limbs chlorophyll reduced odour and enhanced healing, in some cases with exceptional results, e.g. legs saved from seemingly inevitable amputation. Numerous other cases and conditions are mentioned. Chlorophyll was comfortable as a wet dressing and was easily tolerated by patients. The author is convinced that chlorophyll is the best agent known for use in the treatment of suppurative diseases, indolent ulcers or wherever stimulation of tissue repair is desired.. although it is not presented as a cure-all.

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